rFVIII Products Available from Canadian Blood Services1
ADYNOVATE®
Antihemophilic Factor (Recombinant), PEGylated
ELOCTATE® (only available under selective criteria)
Antihemophilic Factor (Recombinant), Fc Fusion Protein
JIVI® (only available under selective criteria)
Antihemophilic Factor (Recombinant, B-domain deleted, PEGylated)
KOVALTRY®
Antihemophilic Factor (Recombinant)
NUWIQ®
Antihemophilic Factor (Recombinant, B-Domain deleted)
XYNTHA®
Antihemophilic Factor (Recombinant, B-Domain deleted)
Choose a category to compare treatment options.
rFVIII Treatment Option |
Select Category
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ADYNOVATE® | Chinese Hamster Ovary (CHO) |
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All2 | BAXJECT II Hi-Flow | ![]() |
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PEGylation |
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ELOCTATE® | Human Embryonic Kidney (HEK) |
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All3 | PFS and Vial Adapter | ![]() |
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Fc Fusion |
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JIVI® | Baby Hamster Kidney (BHK) |
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≥12 years of age4 | PFS and Vial Adapter | ![]() |
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PEGylation |
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KOVALTRY® | Baby Hamster Kidney (BHK) |
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All5 | PFS and Vial Adapter | ![]() |
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No Fusion or PEGylation |
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NUWIQ® | Human Embryonic Kidney (HEK) |
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All6 | PFS and Vial Adapter | ![]() |
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No Fusion or PEGylation |
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XYNTHA® | Chinese Hamster Ovary (CHO) |
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All7 | PFS and Vial Adapter or Solofuse | ![]() |
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No Fusion or PEGylation |
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ADYNOVATE® | ELOCTATE® | JIVI® | KOVALTRY® | NUWIQ® | XYNTHA® | |
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Cell line | Chinese Hamster Ovary (CHO) | Human Embryonic Kidney (HEK) | Baby Hamster Kidney (BHK) | Baby Hamster Kidney (BHK) | Human Embryonic Kidney (HEK) | Chinese Hamster Ovary (CHO) |
On‑demand |
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Prophylaxis† |
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Age Groups | All2 | All3 | ≥12 years of age4 | All5 | All6 | All7 |
Reconstitution device | BAXJECT II Hi-Flow | PFS and Vial Adapter | PFS and Vial Adapter | PFS and Vial Adapter | PFS and Vial Adapter | PFS and Vial Adapter or Solofuse |
Available sizes (250, 500, 1000 and 2000 IU) | ![]() |
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Diluent volume |
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rFVIII modification | PEGylation | Fc Fusion | PEGylation | No Fusion or PEGylation | No Fusion or PEGylation | No Fusion or PEGylation |
Contains non‑medicinal polysorbate or poloxamer (types of PEG) |
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Download the Treatment Options PDF
The comparative information provided in the table above does not convey the relative effectiveness and/or safety of the listed products. As with all treatment options, your licensed healthcare professional must determine what therapy is appropriate for you based on their assessment of your individual treatment needs and goals.
† Prophylaxis is a course of treatment to prevent bleeds.
IU = international units; P188 = poloxamer 188; PFS = pre-filled syringe; PS80 = polysorbate 80
- Available from: https://www.hemophilia.ca/files/CBS%20announces%202018-2020%20contracts.pdf
- Adynovate Product Monograph. Shire Pharma Canada ULC (now part of Takeda Canada Inc.) May 1, 2020.
- Eloctate Product Monograph. Bioverativ Canada Inc. November 21, 2019.
- JIVI Product Monograph. Bayer Inc. October 18, 2018.
- Kovaltry Product Monograph. Bayer Inc. June 28, 2019.
- Nuwiq Product Monograph. Octapharma Canada Inc. December 14, 2018.
- Xyntha Product Monograph. Pfizer Canada Inc. May 11, 2016.