Hemophilia A treatment options

Hemophilia A: Recombinant Factor VIII (rFVIII) Treatment Options

rFVIII Products Available from Canadian Blood Services (2022-2025)1

ADYNOVATE®

Antihemophilic Factor (Recombinant), PEGylated

ELOCTATE® (only available under selective criteria)

Antihemophilic Factor (Recombinant), Fc Fusion Protein

ESPEROCT®

Antihemophilic Factor (Recombinant, B-domain truncated), PEGylated

JIVI® (only available under selective criteria)

Antihemophilic Factor (Recombinant, B-domain deleted), PEGylated

KOVALTRY®

Antihemophilic Factor (Recombinant)

XYNTHA®

Antihemophilic Factor (Recombinant, B-domain deleted)

ZONOVATE®

Antihemophilic Factor (Recombinant, B-domain truncated)

Choose a category to compare treatment options.

rFVIII Treatment Option Select Category
ADYNOVATE® Chinese Hamster Ovary (CHO) All2 BAXJECT II Hi-Flow + 3000 IU
2 or 5 mL (depending on vial)
PEGylation
(PS80)
ELOCTATE® Human Embryonic Kidney (HEK) All3 PFS and Vial Adapter + 750, 1500, and 3000 IU
3 mL
Fc Fusion
(PS80)
ESPEROCT® Chinese Hamster Ovary (CHO) All4 PFS and Vial Adapter + 500, 1000, 1500, 2000, and 3000 IU
4 mL
PEGylation
(PS80)
JIVI® Baby Hamster Kidney (BHK) ≥12 years of age5 PFS and Vial Adapter + 3000 IU
2.5 mL
PEGylation
(PS80)
KOVALTRY® Baby Hamster Kidney (BHK) All6 PFS and Vial Adapter + 3000 IU
2.5 or 5 mL (depending on vial)
No Fusion or PEGylation
(PS80)
XYNTHA® Chinese Hamster Ovary (CHO) All7 PFS and Vial Adapter or Solofuse + 3000 IU
4 mL
No Fusion or PEGylation
(PS80)
ZONOVATE® Chinese Hamster Ovary (CHO) All8 PFS and Vial Adapter + 3000 IU
4 mL
No Fusion or PEGylation
(PS80)
ADYNOVATE® ELOCTATE® ESPEROCT® JIVI® KOVALTRY® XYNTHA® ZONOVATE®
Cell line Chinese Hamster Ovary (CHO) Human Embryonic Kidney (HEK) Chinese Hamster Ovary (CHO) Baby Hamster Kidney (BHK) Baby Hamster Kidney (BHK) Chinese Hamster Ovary (CHO) Chinese Hamster Ovary (CHO)
On‑demand
Prophylaxis†
Age Groups All2 All3 All4 ≥12 years of age5 All6 All7 All8
Reconstitution device BAXJECT II Hi-Flow PFS and Vial Adapter PFS and Vial Adapter PFS and Vial Adapter PFS and Vial Adapter PFS and Vial Adapter or Solofuse PFS and Vial Adapter
Available sizes (250, 500, 1000, and 2000 IU) + 3000 IU + 750, 1500, and 3000 IU + 500, 1000, 1500, 2000, and 3000 IU + 3000 IU + 3000 IU + 3000 IU + 3000 IU
Diluent volume
2 or 5 mL (depending on vial)
3 mL
4 mL
2.5 mL
2.5 or 5 mL (depending on vial)
4 mL
4 mL
rFVIII modification PEGylation Fc Fusion PEGylation PEGylation No Fusion or PEGylation No Fusion or PEGylation No Fusion or PEGylation
Contains non‑medicinal polysorbate or poloxamer (types of PEG)
(PS80)
(PS80)
(PS80)
(PS80)
(PS80)
(PS80)
(PS80)

Download the Treatment Options PDF

The comparative information provided in the table above does not convey the relative effectiveness and/or safety of the listed products. As with all treatment options, your licensed healthcare professional must determine what therapy is appropriate for you based on their assessment of your individual treatment needs and goals.

† Prophylaxis is a course of treatment to prevent bleeds.

IU = international units; PFS = pre-filled syringe; PS80 = polysorbate 80

  1. Available from: https://chscontact.ca/cbs-announces-fviii-and-fix-products-for-2022-2025/
  2. ADYNOVATE Product Monograph. Takeda Canada Inc. November 5, 2021.
  3. ELOCTATE Product Monograph. Bioverativ Canada Inc. November 8, 2021.
  4. ESPEROCT Product Monograph. Novo Nordisk Canada Inc. May 6, 2020.
  5. JIVI Product Monograph. Bayer Inc. October 18, 2018.
  6. KOVALTRY Product Monograph. Bayer Inc. June 28, 2019.
  7. XYNTHA Product Monograph. Pfizer Canada Inc. May 11, 2016.
  8. ZONOVATE Product Monograph. Novo Nordisk Canada Inc. April 12, 2021.
ADYNOVATE is a registered trademark of Baxalta Incorporated.
ELOCTATE is a registered trademark of Bioverativ Therapeutics Inc., an affiliate of Sanofi.
ESPEROCT is a registered trademark of Novo Nordisk Health Care AG and is used under license by Novo Nordisk Canada Inc.
JIVI is a registered trademark of Bayer Inc.
KOVALTRY is a registered trademark of Bayer Inc.
XYNTHA is a registered trademark of Wyeth LLC, owner/Pfizer Canada Inc., Licensee.
ZONOVATE is a registered trademark of Novo Nordisk Health Care AG and is used under license by Novo Nordisk Canada Inc.